Indoc builds medical
research
data platforms  

 
Image by Uriel SC

Advanced medical research requires secure platforms to manage, integrate and analyze complex data from diverse sources. 

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Few organizations have the resources required to build a comprehensive research data platform from the ground up. As a result, the needs of the research community often remain unmet. 

  

Indoc offers an alternative solution.

  

Our open source systems, standards, and policies are reusable. This allows collaborators to focus efforts on their specific requirements rather than building entire platforms from the ground up. 

  

The more collaborators who participate, the more cost effective and interoperable the underlying architecture becomes for everyone. And this allows data to be aggregated and shared across research programs with unprecedented ease.

 

We’re not just building data platforms. 

We’re building a community of data platforms. 

 

News and Events

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Events

News

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Apr. 16, 2016

Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort

The CAN-BIND research program investigates and identifies biomarkers that help to predict outcomes in patients with MDD treated with antidepressant medication. The primary objective of this initial study (known as CAN-BIND-1) is to identify individual and integrated neuroimaging, electrophysiological, molecular, and clinical predictors of response to sequential antidepressant monotherapy and adjunctive therapy in Major Depressive Disorder. Read more

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Oct. 1, 2016

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder

The Depression Inventory Development project is an initiative of the International Society for CNS Drug Development whose goal is to develop a comprehensive and psychometrically sound measurement tool to be utilized as a primary endpoint in clinical trials for major depressive disorder. Read more

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Apr. 23, 2017

Indoc presents at the CFN 2017 Annual National Conference

Indoc CEO, Ken Evans presents on building platforms and processes for data sharing at the 2017 Canadian Frailty Network's National Conference on Frailty.

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May 22, 2017

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment. Read more

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Aug. 7, 2017

Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the Canadian biomarker integration network in depression

Among the complexities of conducting multi-site studies and increasing the shelf life of biological data beyond the original study are timely standardization and documentation of relevant study parameters. We present the insights gained and guidelines established within the EEG working group of the Canadian Biomarker Integration Network in Depression (CAN-BIND). Read more

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Nov. 14, 2017

Ontario Brain Institute releases open data on autism to enable faster scientific breakthroughs

Ontario Brain Institute’s (OBI) neuroinformatics platform Brain-CODE with support from Indoc, offers open access to data for the first time. The high-resolution Magnetic Resonance (MR) imaging mouse model data will help researchers explore how autism affects the brain and accelerate the discovery process leading to better treatments and improved health impact. Read more

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Jan. 1, 2018

Performance of the biological rhythms interview for assessment in neuropsychiatry: An item response theory and actigraphy analysis

Biological rhythm disturbances are widely associated with the pathophysiology of mood disorders. The Biological Rhythms Interview for Assessment in Neuropsychiatry (BRIAN) is a self-report that indexes rhythm disturbance in sleep, activity, social and eating patterns. The aim of this study was to perform an Item Response Theory (IRT) analysis of the BRIAN and investigate its associations with objective sleep and rhythm disturbance measures. Read more

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May 23, 2018

Brain-CODE: A Secure Neuroinformatics Platform for Management, Federation, Sharing and Analysis of Multi-Dimensional Neuroscience Data

Historically, research databases have existed in isolation with no practical avenue for sharing or pooling medical data into high dimensional datasets that can be efficiently compared across databases. To address this challenge, the Ontario Brain Institute's "Brain-CODE" is a large-scale neuroinformatics platform designed to support the collection, storage, federation, sharing and analysis of different data types across several brain disorders, as a means to understand common underlying causes of brain dysfunction and develop novel approaches to treatment. Read more

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Jul. 18, 2018

The Toronto Cognitive Assessment (TorCA): normative data and validation to detect amnestic mild cognitive impairment

A need exists for easily administered assessment tools to detect mild cognitive changes that are more comprehensive than screening tests but shorter than a neuropsychological battery and that can be administered by physicians, as well as any health care professional or trained assistant in any medical setting. The Toronto Cognitive Assessment (TorCA) was developed to achieve these goals. Read more

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Aug. 1, 2018

Indoc and OBI present on Brain-CODE and its privacy preserving record linkage protocol at IPDLC 2018

Indoc Research and the Ontario Brain Institute present at the International Population Data Linkage Conference 2018. Indoc introduces Brain-CODE, and describes how it enables integrative analyses, while also providing the opportunity to leverage existing clinical administrative data holdings through privacy preserving linkage with external data sets.

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Nov. 6, 2018

The CAMH Neuroinformatics Platform: A Hospital-Focused Brain-CODE Implementation

Aggregation of high-dimensional datasets across brain disorders can increase sample sizes and may help identify underlying causes of brain dysfunction, however, additional barriers exist for effective data harmonization and integration for their combined use in research. To help realize the potential of multi-modal data integration for the study of mental illness, the Centre for Addiction and Mental Health (CAMH) constructed a centralized data capture, visualization and analytics environment-the CAMH NeuroinformaticsPlatform-based on the Ontario Brain Institute (OBI) Brain-CODE architecture. Read more

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Nov. 27, 2018

CANARIE funds Indoc and OBI to develop research portal software

To address the research data management needs of researchers studying disorders of the brain and other disease areas, Indoc Research and the Ontario Brain Institute will develop data portal software that will enable research teams to securely and seamlessly capture, query, and visualize patient data; collaborate and share datasets; and access support and training resources. Read more